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Succinate dehydrogenase subunit E : ウィキペディア英語版 | Succinate dehydrogenase subunit E
In molecular biology, the protein domain named Sdh5 is also named SdhE which stands for succinate dehydrogenase protein E. In the past, it has also been named YgfY and DUF339. Another name for sdhE is succinate dehydrogenase assembly factor 2 (sdhaf2).〔http://www.genecards.org/cgi-bin/carddisp.pl?gene=SDHAF2〕 This protein belongs to a group of highly conserved small proteins found in both eukaryotes and prokaryotes, including NMA1147 from ''Neisseria meningitidis'' and YgfY from ''Escherichia coli''. The SdhE protein is found on the mitochondrial membrane is it is important for creating energy via a process named the electron transport chain. ==Function== The function of SDHE has been described as a flavinator of succinate dehydrogenase. SdhE works as a co-factor chaperone that incorporates FAD into SdhA. This results in SdhA flavinylation which is required for the proper function succinate dehydrogenase. More recent scientific studies indicate that SdhE is required by bacteria in order to grow on succinate, using succinate as its only source of carbon and additionally for the function, of succinate dehydrogenase, a vital component of the electron transport chain which produces energy.
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